They also knew that the compensatory rise in reductase was something to be prevented.
ML-236B became Endos first experimental statin.
A pharmaceutical consultant called Dr Richard Cenedella said: I have consulted for many drug companies over the years.This also explains why high HDL would be seen as good.It follows that the life of every cell in the human body is catastrophically impaired by statins.When someone takes statins, the cells are impaired from making cholesterol so they try to take the cholesterol from the blood stream.(p14) In 1980, Brown and Goldstein co-authored a paper in The Journal of Lipid Research stating: Incubation of cultured cells with compactin blocks mevalonate production and converts the cells into mevalonate auxotrophs.Before a cell divides, it replicates its DNA and the new cell can be formed from the same blueprint.MacDonald had to admit to liver cell damage in dogs but, again, got away with We clearly do not understand the mechanism.Merck called Sankyo to try to learn from this and Sankyo told them to sod off quite right!It was known that statins blocked the mevalonate pathway.The book takes one drug company, Merck, and the American Food Drug Administration (FDA) and a number of other related bodies (e.g.
Within minutes of adding back a small amount of mevalonate, DNA replication and cell cycles were completely restored.
An FH sufferer can therefore have heart problems because of too little LDL reaching the heart cells not because of too much LDL!
They know not what they have done.
In 1982 Brown and Goldstein wrote in The Proceedings of the National Academy of Sciences : If reducatase cannot increase sufficiently to overcome the inhibition by compactin, the cells die.Dr Hunninghake: Astra Zeneca, Bristol-Myers Squibb, rabattkod photomic 2015 Kos, Merck, Novartis, Pfizer.Dr Bairey: Astra Zeneca, Bayer, google presentation examples Bristol-Myers Squibb, Kos, Merck, Novartis, Pfizer, Procter Gamble, Wyeth.Without the cholesterol and isoprenoids made by the mevalonate pathway, none of this cell rejuvenation happens.If cells cannot replicate, they inevitably die.The scandal has been brilliant, meticulously planned and success guaranteed.Dr Clark: Abbot, Astra Zeneca, Bristol-Myers Squibb, Merck, Pfizer.In March 1988 he stated that to date there had been no cataracts seen in humans taking lovastatin.